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ENTROPY OF LEUKOCYTE FORMULA AS BIOLOGICAL AGEING MARKER
E. Golovanova, L. Dubenskaya, S. Bazhenov
The ageing is characterized by breaches in principal homeostatic systems with leading role of cardio-vascular system and reduce of adaptation possibilities.
These abnormalities can be estimated due to entropy methods of biological systems analysis.
Aim: studying of leukocyte formula parameters depending on biological ageing rate.
Methods: 167 patients from 25 to 90 years old with arterial hypertension were examined. They were divided into 2 groups. In the first subgroup of 72 patients average age was 49,15,8, in the second subgroup of 95 patients average age was 76,85,3 years.
Biological ageing rate was counted on application of multiple linear regression analysis with the use of clinical and physiological markers.
The relative entropy of leukocyte formula (RELF) was estimated by Shannon C. The meanings of RELF from 56 to 67% were considered adaptive physiological limits.
Results and discussion: Reliable differences of stab neutrophilocytes in according to ageing rate (4,42,4 ? with slow, 9,122,9 ? with fast, p<0,001) were revealed statistically. Leukocytes formula entropy depends on ageing rate with mature patients (55,15,8% ? with slow rate; 59,95,0% ? with normal, p1<0,05; 67,87,2% ? with fast, p2<0,001), both in elderly and senile patients (63,44,4 ?with slow rate, 69,15,5 ? with fast rate; p<0,01). No significant differences were determined in fast ageing rate between the first and second groups, that points out great influence of cardio-vascular component on ageing rate of mature patients with hypertension.
Conclusion: High parameters of structural entropy in background of stab neutrophilocytes displacement may be additional markers of the fast ageing rate in mature, elderly and senile patients with arterial hypertension.
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